Whom plays Mrs. Wheeler Wheeler? Which actor assumes the role of Karen Wheeler in the show? Whom is the performer behind Karen Wheeler? Mrs. Wheeler is brought to life by which actress? Who plays the character of Karen Wheeler on the series? Whom is the talent bringing Karen Wheeler's character to life? What performer takes on the role of Karen Wheeler in the television show? Whoever takes on the part of Karen Mrs. Wheeler? Whom is the talented individual portraying Karen the mother on the show? What actor brings the character of Karen Mrs. Wheeler to the screen?